Raymond A Sobel Selected Research

Experimental Autoimmune Encephalomyelitis (Encephalomyelitis, Autoimmune Experimental)

1/2019	DGAT1 inhibits retinol-dependent regulatory T cell formation and mediates autoimmune encephalomyelitis.
1/2019	IL-11 Induces Encephalitogenic Th17 Cells in Multiple Sclerosis and Experimental Autoimmune Encephalomyelitis.
10/2016	Anti-CD48 Monoclonal Antibody Attenuates Experimental Autoimmune Encephalomyelitis by Limiting the Number of Pathogenic CD4+ T Cells.
10/2016	Treatment of spontaneous EAE by laquinimod reduces Tfh, B cell aggregates, and disease progression.
4/2016	CNS accumulation of regulatory B cells is VLA-4-dependent.
11/2015	IL-21R signaling is critical for induction of spontaneous experimental autoimmune encephalomyelitis.
5/2015	B-cell very late antigen-4 deficiency reduces leukocyte recruitment and susceptibility to central nervous system autoimmunity.
8/2014	Immunodominant T-cell epitopes of MOG reside in its transmembrane and cytoplasmic domains in EAE.
5/2014	Uncovering cryptic glycan markers in multiple sclerosis (MS) and experimental autoimmune encephalomyelitis (EAE).
1/2014	SJL mice infected with Acanthamoeba castellanii develop central nervous system autoimmunity through the generation of cross-reactive T cells for myelin antigens.

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Raymond A Sobel Research Topics

Disease

39	Experimental Autoimmune Encephalomyelitis (Encephalomyelitis, Autoimmune Experimental) 01/2019 - 03/2002
32	Multiple Sclerosis 01/2022 - 08/2002
13	Autoimmune Diseases (Autoimmune Disease) 12/2016 - 01/2002
12	Inflammation (Inflammations) 01/2021 - 07/2007
10	Infections 10/2017 - 01/2002
9	Demyelinating Diseases (Demyelinating Disease) 01/2017 - 11/2002
8	Paralysis (Palsy) 05/2017 - 11/2002
6	Meningitis 05/2009 - 08/2002
4	Neuromyelitis Optica (Devic's Disease) 05/2017 - 09/2006
4	Neuroinflammatory Diseases 11/2013 - 11/2005
3	Encephalomyelitis (Myeloencephalitis) 01/2019 - 12/2011
3	Body Weight (Weight, Body) 05/2009 - 08/2002
2	Myocarditis (Carditis) 01/2018 - 12/2016
2	Disease Progression 10/2016 - 07/2013
2	Brain Diseases (Brain Disorder) 01/2011 - 01/2007
2	Neoplasms (Cancer) 08/2010 - 09/2002
2	Meningoencephalitis 04/2009 - 04/2004
2	Optic Neuritis (Retrobulbar Neuritis) 09/2006 - 05/2003
2	Hypothermia 05/2003 - 05/2003
2	Stroke (Strokes) 05/2003 - 05/2003
2	Pancytopenia 02/2003 - 08/2002
2	Necrosis 11/2002 - 01/2002
1	Atrial Fibrillation 01/2018
1	Dilated Cardiomyopathy (Cardiomyopathy, Congestive) 01/2018
1	Heart Failure 01/2018
1	Chagas Disease (American Trypanosomiasis) 10/2017
1	Chronic Disease (Chronic Diseases) 10/2017
1	Nervous System Diseases (Neurological Disorders) 05/2014
1	Amebiasis (Amoebiasis) 01/2014
1	Central Nervous System Diseases (CNS Diseases) 01/2014

Drug/Important Bio-Agent (IBA)

12	AutoantigensIBA 01/2018 - 05/2003
12	Proteins (Proteins, Gene)FDA Link 10/2016 - 08/2002
9	Peptides (Polypeptides)IBA 04/2016 - 03/2002
9	CytokinesIBA 12/2011 - 01/2002
8	Myelin-Oligodendrocyte GlycoproteinIBA 10/2016 - 05/2003
7	AntigensIBA 12/2016 - 09/2006
6	EpitopesIBA 01/2018 - 02/2006
6	AntibodiesIBA 05/2017 - 01/2006
5	Interleukin-17 (Interleukin 17)IBA 12/2016 - 07/2007
4	Messenger RNA (mRNA)IBA 01/2019 - 02/2003
4	AutoantibodiesIBA 01/2018 - 01/2006
4	liposomal amphotericin B FDA Link 10/2017 - 08/2002
4	Cyclophosphamide (Cytoxan)FDA LinkGeneric 10/2017 - 08/2002
4	LigandsIBA 07/2012 - 01/2004
4	Pharmaceutical PreparationsIBA 01/2012 - 08/2007
4	Amphotericin B (Amphotericin)FDA LinkGeneric 05/2009 - 08/2002
4	Tumor Necrosis Factor-alpha (Tumor Necrosis Factor)IBA 08/2007 - 01/2002
3	Monoclonal AntibodiesIBA 10/2016 - 01/2012
3	Interleukin-10 (Interleukin 10)IBA 02/2015 - 04/2004
3	Interleukin-6 (Interleukin 6)IBA 04/2013 - 04/2004
3	InterferonsIBA 09/2012 - 01/2002
3	Membrane Proteins (Integral Membrane Proteins)IBA 02/2008 - 01/2002
3	Myelin Proteolipid ProteinIBA 10/2007 - 07/2004
3	Fluconazole (Zonal)FDA LinkGeneric 09/2007 - 08/2002
2	T-Lymphocyte Epitopes (Epitopes, T Lymphocyte)IBA 01/2018 - 12/2016
2	laquinimodIBA 10/2016 - 01/2012
2	Transcription Factors (Transcription Factor)IBA 04/2016 - 05/2003
2	Integrin alpha4beta1 (VLA-4)IBA 04/2016 - 05/2015
2	Amino Acids FDA Link 08/2014 - 04/2013
2	myelin proteolipid protein (139-151)IBA 01/2014 - 10/2007
2	ChemokinesIBA 01/2014 - 11/2009
2	Insulin (Novolin)FDA Link 04/2013 - 05/2006
2	Amyloid (Amyloid Fibrils)IBA 04/2013 - 10/2012
2	Small Heat-Shock ProteinsIBA 04/2013 - 10/2012
2	Therapeutic UsesIBA 04/2013 - 08/2007
2	Crystallins (Crystallin)IBA 04/2013 - 07/2007
2	MucinsIBA 09/2012 - 07/2012
2	Glucose (Dextrose)FDA LinkGeneric 05/2009 - 08/2002
2	LipidsIBA 05/2009 - 01/2006
2	Interleukin-12 (IL 12)IBA 08/2007 - 11/2002
2	InterleukinsIBA 08/2007 - 01/2002
2	I-kappa B KinaseIBA 07/2007 - 05/2003
2	Itraconazole (Sporanox)FDA LinkGeneric 03/2007 - 02/2003
2	Interleukin-4 (Interleukin 4)IBA 07/2004 - 04/2004
2	Nitric Oxide Synthase Type II (Inducible Nitric Oxide Synthase)IBA 04/2004 - 05/2003
1	Azetidinecarboxylic AcidIBA 01/2022
1	PolyaminesIBA 01/2021
1	EnzymesIBA 01/2019
1	Retinyl EstersIBA 01/2019
1	Triglycerides (Triacylglycerol)IBA 01/2019
1	Vitamin A (Retinol)FDA LinkGeneric 01/2019
1	Interleukin-11 (Interleukin 11)IBA 01/2019
1	Adenosine Triphosphatases (ATPase)IBA 01/2018
1	CalciumIBA 01/2018
1	Retinaldehyde (Retinal)IBA 01/2017
1	Adenine Nucleotide Translocator 1IBA 12/2016
1	Mitochondrial Proteins (Mitochondrial Protein)IBA 12/2016
1	FumaratesIBA 04/2016
1	Dimethyl FumarateIBA 04/2016
1	interleukin-21 (interleukin 21)IBA 11/2015
1	Natalizumab (Tysabri)FDA Link 05/2015
1	peptide PIBA 08/2014
1	Polysaccharides (Glycans)IBA 05/2014
1	Formyl Peptide Receptors (Formyl Peptide Receptor)IBA 01/2014
1	myelin basic protein 89-101IBA 01/2014
1	Phosphates (Orthophosphate)IBA 11/2013
1	Fingolimod Hydrochloride (FTY720)FDA Link 11/2013
1	SphingosineIBA 11/2013

Therapy/Procedure

11	Therapeutics 10/2017 - 02/2003
1	Intranasal Administration 01/2016